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Article

Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer.

Cellular signalling - 1 Jan 2017

Xu Yanfeng, Zhao Yinghui, Xu Yanli, Guan Yu, Zhang Xiao, Chen Yan, Wu Qi, Zhu Guoqing, Chen Yuxin, Sun Fenyong, Wang Jiayi, Yu Yongchun

Abstract excerpt

Chemotherapy is critical for the treatment of liver cancer. Despite the pro-apoptotic effects of corosolic acid (CA) have been revealed, the methods to enhance its efficacy are unclear. The aim of this study is to investigate the target that might reduce CA efficacy and figure out the way to conquer it. We found reduction of Yes-associated protein (YAP) might be a critical event that suppresses efficacy of CA....

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Identifiers

PMID: 27836738
DOI: 10.1016/j.cellsig.2016.11.001

Genes

LATS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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