Article
Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Sept 2018
Chang Hang-Lung, Chen Hsin-An, Bamodu Oluwaseun Adebayo, Lee Kwai-Fong, Tzeng Yew-Min, Lee Wei-Hwa, Tsai Jo-Ting
Abstract excerpt
The cancer stem cells (CSCs) theory recently became a focus of heightened attention in cancer biology, with the proposition that CSCs may constitute an important therapeutic target for effective anticancer therapy, because of their demonstrated role in tumor initiation, chemo-, and radio-resistance. Liver CSCs are a small subpopulation of poorly- or undifferentiated liver tumor cells, implicated in tumorigenesis,...
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