Article
Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells.
Cell death & disease - 5 Oct 2017
Wang Sen, Wang Kexin, Zhang Chundong, Zhang Wanfeng, Xu Qian, Wang Yitao, Zhang Yulin, Li Yi, Zhang Ying, Zhu Huifang, Song Fangzhou, Lei Yunlong, Bu Youquan
Abstract excerpt
Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the AKT-MTOR signaling pathway. Inhibition of autophagy by either administration of autophagic...
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