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Article

YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression

7 May 2021

Abstract excerpt

Colorectal cancer (CRC) is one of the most aggressive and lethal cancers. The role of autophagy in the pathobiology of CRC is intricate, with opposing functions manifested in different cellular contexts. The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor-suppressor pathway, functions as an oncoprotein in a variety of cancers. In this study, we found that YAP could...

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PMID: 33963173
DOI: 10.1038/s41419-021-03722-8

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