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Tomatidine improves liver fibrosis by promoting autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 pathway

2023-04-27

Abstract excerpt

Liver fibrosis is caused by various liver diseases and eventually develops into liver cancer. Tomatidine (TD), an aglycone of α-tomatidine, is a major glycoalkaloid found in immature tomato fruits, leaves, and stems. In this study, we investigated that tomatidine may promote autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 signaling pathway to improve liver fibrosis and combined experimental vali...

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Literature Corpus work
60f44f32-eaff-5367-b278-c9ff9adcb074
DOI
10.21203/rs.3.rs-2761910/v1
Open publication

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