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Cell Cycle Arrest and Autophagy Induced by Compound Kushen Injection in sw620 and sw480 Colorectal Cancer Cells with p53 Mutation

2019-07-24

Abstract excerpt

<h4>Background: </h4> Compound Kushen Injection (CKI) has been clinically used in China for 15 years to treat various types of solid tumors, including colorectal cancer. Here we examine cell cycle arrest, induced autophagy, and mutant p53 pathways perturbed by CKI in colorectal cancer cells. We and other groups have shown that CKI alters p53 gene expression patterns and suppresses proliferation in colorectal cance...

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Literature Corpus work
7ecc3136-410f-5599-8d16-0ca775f0a7b5
DOI
10.21203/rs.2.11913/v1
Open publication

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