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Article

66034T/C polymorphism of the human pregnane X receptor (hPXR) as potential risk factor for drug resistance in epilepsy - Preliminary study.

Neurologia i neurochirurgia polska - 1 Jan 2000

Kozera-Kępniak Alicja, Jastrzębski Karol, Walenczak Jakub, Klimek Andrzej, Głąbiński Andrzej

Abstract excerpt

INTRODUCTION AND OBJECTIVES: Recent research has suggested that genetic factors may play an important role in the development of drug resistance in epilepsy. It is not clear which gene loci are responsible for the drug-resistant phenotype. Studying certain nuclear receptors may be helpful in predicting drug response, as they regulate drug transporting proteins and enzymes involved in their metabolism. This study...

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PMID: 27836114
DOI: 10.1016/j.pjnns.2016.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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