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Association between Genetic Polymorphism of SCN1A, GABRA1 and ABCB1 and Drug Responsiveness in Vietnamese Epileptic Children.

Medicina (Kaunas, Lithuania) - 16 Apr 2024

Tang Hai Xuan, Ho Muoi Dang, Vu Nhung Phuong, Cao Hung Vu, Ngo Vinh Anh, Nguyen Van Thi, Nguyen Thuan Duc, Nguyen Ton Dang

Abstract excerpt

Background and Objectives: Drug resistant epilepsy (DRE) is a major hurdle in epilepsy, which hinders clinical care, patients' management and treatment outcomes. DRE may partially result from genetic variants that alter proteins responsible for drug targets and drug transporters in the brain. We aimed to examine the relationship between SCN1A, GABRA1 and ABCB1 polymorphism and drug response in epilepsy children...

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Identifiers

PMID: 38674283
DOI: 10.3390/medicina60040637
PMCID: PMC11052159

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