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Article

Association of xenobiotic receptor polymorphisms with carbamazepine response in epilepsy patients.

Gene - 1 Mar 2021

Kong Fan-Cheng, Ma Chun-Lai, Lang Li-Qin, Zhong Ming-Kang

Abstract excerpt

PURPOSE: Drug-resistant epilepsy is a problem worldwide. Xenobiotic receptors may play a significant role in the establishment of resistance to antiepileptic agents. Previous studies have confirmed that the metabolism and efficacy of carbamazepine (CBZ) can be influenced by xenobiotic receptors, especially pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AHR)....

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Identifiers

PMID: 33333223
DOI: 10.1016/j.gene.2020.145359

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