Article
Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis.
Atherosclerosis - 1 Dec 2016
Hueso Miguel, De Ramon Laura, Navarro Estanislao, Ripoll Elia, Cruzado Josep M, Grinyo Josep M, Torras Joan
Abstract excerpt
BACKGROUND AND AIMS: CD40/CD40L signaling exerts a critical role in the development of atherosclerosis, and microRNAs (miRNAs) are key regulators in vascular inflammation and plaque formation. In this work, we investigated mRNA/miRNA expression during progression of atherosclerotic lesions through CD40 silencing. METHODS: We silenced CD40 with a specific siRNA in ApoE-/- mice and compared expression of mRNA/miRNA...
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