Article
Regulation and mechanism of mouse miR-130a/b in metabolism-related inflammation.
The international journal of biochemistry & cell biology - 1 May 2016
Zheng Hailiang, Dong Xiangkun, Liu Na, Xia Wenmin, Zhou Lulu, Chen Xiaojun, Yang Zaiqing, Chen Xiaodong
Abstract excerpt
Increasing evidence suggests that microRNAs are involved in regulating immune response and metabolism, which are among the most fundamental requirements for survival. Here we investigate the contribution and mechanism of microRNA-130a/b in controlling metabolism-related inflammation. Our findings indicate that miR-130a/b significantly inhibits TNFα and Sp1 expression by directly binding to their 3'-untranslated...
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