Article

In vivo inhibition of miR-125b modulates monocyte trafficking through the CCR7 receptor and attenuates atherosclerosis

2024-03-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Atherosclerosis (ATH) is a chronic systemic inflammatory disease affecting the vessel wall, wherein regulating non-coding RNAs play a crucial role. We previously demonstrated that miR-125b is upregulated in ATH and is a main regulator of cholesterol metabolism in macrophages. Herein we hypothesized that inhibiting miR-125b may attenuate ATH. <h4>Methods and results</h4> In the...

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Literature Corpus work: 55a9eb96-af6a-5102-8cd9-804220628c7d
DOI: 10.1101/2024.03.25.24304874

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