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Article

MicroRNA-26b-/- augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis.

Cardiovascular research - 31 Dec 2025

Peters Linsey J F, Bidzhekov Kiril, Bonnin-Marquez Andrea, Sundararaman Sai Sahana, Huchzermeier Rosanna, Maas Sanne L, Abschlag Kathrin, Jans Alexander, Lin Cheng, Haberbosch Markus, Jansen Yvonne, Yu Baixue, Sluimer Judith C, Gijbels Marion J, Jankowski Joachim, Bartneck Matthias, Biessen Erik A L, Weber Christian, Döring Yvonne, van der Vorst Emiel P C

Abstract excerpt

AIMS: Increasing evidence has shown that microRNAs (miRs) play a fundamental role in atherosclerosis, but the exact role of various miRs remains elusive. Preliminary data showed that, with a five-fold increase, miR-26b was highly expressed in human atherosclerotic plaques compared to healthy vessels. Therefore, we aimed to determine its cell-specific effects on atherosclerosis development and its therapeutic...

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Identifiers

PMID: 41223017
DOI: 10.1093/cvr/cvaf234
PMCID: PMC12754845

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