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Article

Clinical Implications of p16 Evaluation in a Purposively Sampled Cohort of High-Risk Breast Cancer Phenotypes.

International journal of molecular sciences - 3 May 2026

Anton Sorana Caterina, Nedelcu Alin Horațiu, Anton Carmen Rodica, Morariu Ionela Daniela, Lupu Ancuța, Dăscălescu Gabriel, Ciobîcă Alin, Lupu Vasile Valeriu, Knieling Anton, Crauciuc Dragoș Valentin, Eduard Carp, Tirnovanu Mihaela, Dondiuc Iurie, Ilea Ciprian, Anton Emil

Abstract excerpt

The overexpression of cyclin-dependent kinase inhibitor p16 (INK4a) is widely recognized as a surrogate marker for high-risk human papillomavirus (HPV) in anogenital malignancies, but its significance in invasive breast carcinoma is complex and remains frequently debated. While historically investigated as a viral proxy, emerging evidence suggests that elevated p16 levels in breast tissue may instead reflect...

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Identifiers

PMID: 42123675
DOI: 10.3390/ijms27094097
PMCID: PMC13164544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Clinical Implications of p16 Evaluation in a Purposively Sampled Cohort of High-Risk Breast Cancer Phenotypes.PMID 42123675Read ↗

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