Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer.

doi:10.1002/2056-4538.70012

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Article

Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer.

The journal of pathology. Clinical research - 1 Jan 2025

Gorbokon Natalia, Wößner Niklas, Ahlburg Viktoria, Plage Henning, Hofbauer Sebastian, Furlano Kira, Weinberger Sarah, Bruch Paul Giacomo, Schallenberg Simon, Roßner Florian, Elezkurtaj Sefer, Lennartz Maximilian, Blessin Niclas C, Marx Andreas H, Samtleben Henrik, Fisch Margit, Rink Michael, Slojewski Marcin, Kaczmarek Krystian, Ecke Thorsten, Klatte Tobias, Koch Stefan, Adamini Nico, Minner Sarah, Simon Ronald, Sauter Guido, Zecha Henrik, Horst David, Schlomm Thorsten, Bubendorf Lukas, Kluth Martina

Abstract excerpt

Homozygous 9p21 deletions usually result in a complete loss of S-methyl-5'-thioadenosine phosphorylase (MTAP) expression visualizable by immunohistochemistry (IHC). MTAP deficiency has been proposed as a marker for predicting targeted treatment response. A tissue microarray including 2,710 urothelial bladder carcinomas were analyzed for 9p21 deletion by fluorescence in situ hybridization and MTAP expression by...

Topics

Humans
Urinary Bladder Neoplasms
Purine-Nucleoside Phosphorylase
Male
Female
Chromosomes, Human, Pair 9
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Middle Aged

Phenotype

Homozygote

Chromosome Deletion

Biomarkers, Tumor

In Situ Hybridization, Fluorescence

Tissue Array Analysis

Immunohistochemistry

Adult

Aged, 80 and over

Source

Open in PubMed Open full text

Identifiers

PMID: 39668577
DOI: 10.1002/2056-4538.70012
PMCID: PMC11638363

Genes

MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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