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Article

Genome-wide association studies: potential next steps on a genetic journey.

Human molecular genetics - 15 Oct 2008

McCarthy Mark I, Hirschhorn Joel N

Abstract excerpt

Genome-wide association studies have successfully identified numerous loci at which common variants influence disease risk or quantitative traits. Despite these successes, the variants identified by these studies have generally explained only a small fraction of the heritable component of disease risk, and have not pinpointed with certainty the causal variant(s) at the associated loci. Furthermore, the mechanisms...

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PMID: 18852205
DOI: 10.1093/hmg/ddn289
PMCID: PMC2782356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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