Article
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.
Cell death & disease - 10 Nov 2016
de Mingo Álvaro, de Gregorio Estefanía, Moles Anna, Tarrats Núria, Tutusaus Anna, Colell Anna, Fernandez-Checa Jose C, Morales Albert, Marí Montserrat
Abstract excerpt
Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation, having SIRT1 as a substrate. We investigated the roles of CTSB/S and SIRT1 in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal...
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