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Article

Non-redundant roles of cathepsins in promoting necrosis of human macrophages

2026-02-02

Abstract excerpt

<title>Abstract</title> <p>Macrophages can undergo inflammatory cell death via pyroptosis, an inflammasome-driven process mediated by caspase-1 and the pore-forming protein gasdermin D, or through alternative necrotic mechanisms triggered by lysosomal disruption involving cysteine cathepsins. However, the contributions of individual cysteine cathepsins to these pathways remain poorly defined, with overlapping rol...

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Literature Corpus work
82788cbd-d584-53ce-972b-a91ef61ec064
DOI
10.21203/rs.3.rs-8472229/v1
Open publication

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Non-redundant roles of cathepsins in promoting necrosis of human macrophagesDOI 10.21203/rs.3.rs-8472229/v1
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