Article
Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB.
Cell death & disease - 6 Oct 2016
Cui Xiaolan, Chen Qian, Dong Zhen, Xu Longmei, Lu Tianfei, Li Dawei, Zhang Jiangjun, Zhang Ming, Xia Qiang
Abstract excerpt
Sirtuin 1 (Sirt1) is a deacetylase that regulates many cellular processes in the liver, and so far its role in endotoxemic liver injury is elusive. So we conditionally inactivate Sirt1 in murine hepatocytes to determine its role in d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver damage, which is a well-established experimental model mimicking septic liver injury and fulminant hepatitis. Ablation of...
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