SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME – IL18 Axis in Human and Mouse Liver Transplantation

Abstract excerpt

<title>Abstract</title> <p>Sirtuin 1 (SIRT1) is a histone/protein deacetylase involved in cellular senescence, inflammation, and stress resistance. We previously reported that myeloid SIRT1 signaling regulates the inflamed liver’s canonical pyroptosis cell death pathway. However, whether/how hepatocyte SIRT1 is engaged in programmed cell death in the cold-stressed liver remains uncertain. Here, we undertook trans...

Topics

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• Biochemical effects in animals
• Carbon Tetrachloride
• Chemical and Drug Induced Liver Injury
• Collagen Type I
• Genomics, phytochemicals, and oxidative stress
• Liver Disease Diagnosis and Treatment
• Sirtuin 1
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

8a8e3163-4de9-5c37-a1f1-1ae9eff8f489

DOI

10.21203/rs.3.rs-2986981/v1