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Article

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2018

Li Min, Hong Wenxuan, Hao Chenzhi, Li Luyang, Wu Dongmei, Shen Aiguo, Lu Jun, Zheng Yuanlin, Li Ping, Xu Yong

Abstract excerpt

Hepatic stellate cells (HSCs) are a major source of fibrogenesis in the liver, contributing to cirrhosis. When activated, HSCs transdifferentiate into myofibroblasts and undergo profound functional alterations paralleling an overhaul of the transcriptome, the mechanism of which remains largely undefined. We investigated the involvement of the class III deacetylase sirtuin [silent information regulator 1 (SIRT1)]...

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Source

Identifiers

PMID: 28970250
DOI: 10.1096/fj.201700612R

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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