Article
SLC22A2 - mapping genomic variations within South African indigenous and admixed populations.
Drug metabolism and personalized therapy - 1 Dec 2016
Pearce Brendon, Jacobs Clifford, Hoosain Nisreen, Benjeddou Mongi
Abstract excerpt
BACKGROUND: The SLC22A2 gene is a polyspecific transporter that mediates the electrogenic transport of small organic cations with different molecular structures. Furthermore, single-nucleotide polymorphisms (SNPs) of SLC22A2 are clinically significant because they can alter the transport of substrate drugs and may, thus, influence the efficacy and toxicity thereof. Additionally, further studies have reported that...
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