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Article

Single nucleotide polymorphisms of the SLC22A2 gene within the Xhosa population of South Africa.

Drug metabolism and pharmacokinetics - 1 Dec 2015

Jacobs Clifford, Pearce Brendon, Du Plessis Mornè, Hoosain Nisreen, Benjeddou Mongi

Abstract excerpt

Human organic cation transporter 2 (hOCT2) is thought to play a critical role in the uptake, pharmacological effects and/or adverse effects of many cationic clinical therapeutics and xenobiotics. Moreover, genetic variations in hOCT2 gene, SLC22A2, are increasingly being recognized as a possible mechanism that can explain individual variation in drug response. To screen for variations in this gene, SLC22A2 was...

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PMID: 26674735
DOI: 10.1016/j.dmpk.2015.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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