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Effects of Xhosa specific solute carrier family 22-member 2 haplotypes on the cellular uptake of metformin and cimetidine.

Gene - 10 Feb 2025

Abrahams-October Zainonesa, Kippie Yunus, Pearce Keenau, Johnson Rabia, Benjeddou Mongi

Abstract excerpt

BACKGROUND: Studies have shown that solute carrier transporters play an important role in the transport and distribution of metformin, and that genetic variation(s) in solute carrier genes have play a role in the variation of metformin efficacy and disposition observed in populations. This study aimed to determine the cellular uptake efficiency of metformin in SLC22A2 coding haplotypes of an indigenous South...

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PMID: 39653092
DOI: 10.1016/j.gene.2024.149157

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