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Article

Label/quencher-free detection of single-nucleotide changes in DNA using isothermal amplification and G-quadruplexes.

The Analyst - 28 Nov 2016

Lee Il Joon, Goo Nam-In, Kim Dong-Eun

Abstract excerpt

We report an analytical method that exploits the interaction between G-quadruplexes and thioflavin T (ThT), for detecting mutant DNA species containing single-base changes. This system is a label/quencher-free fluorescence enhancement system based on rolling circle amplification (RCA)-responsive G-quadruplex formation, which enables a highly selective detection of T790M SNPs in the gene encoding the epidermal...

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PMID: 27827492
DOI: 10.1039/c6an01600f

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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