Fluorescence energy transfer detection as a homogeneous DNA diagnostic method.

doi:10.1073/pnas.94.20.10756

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Article

Fluorescence energy transfer detection as a homogeneous DNA diagnostic method.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 1997

Chen X, Zehnbauer B, Gnirke A, Kwok P Y

Abstract excerpt

A homogeneous DNA diagnostic assay based on template-directed primer extension detected by fluorescence resonance energy transfer, named template-directed dye-terminator incorporation (TDI) assay, has been developed for mutation detection and high throughput genome analysis. Here, we report the s...

Topics

Cystic Fibrosis Transmembrane Conductance Regulator
Drosophila Proteins
Energy Transfer
Fluorescence
Genetic Diseases, Inborn
Genetic Techniques
Genotype
HLA Antigens
Hemochromatosis Protein
Heterozygote
Histocompatibility Antigens Class I
Homozygote
Humans
Membrane Proteins
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases

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Identifiers

PMID: 9380706
DOI: 10.1073/pnas.94.20.10756
PMCID: PMC23476

Genes

CFTR
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9380706-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

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Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.