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Article

One-step isothermal detection of multiple KRAS mutations by forming SNP specific hairpins on a gold nanoshell.

The Analyst - 23 Jul 2018

Chung Chan Ho, Kim Joong Hyun

Abstract excerpt

We developed a one-step isothermal method for typing multiple KRAS mutations using a designed set of primers to form a hairpin on a gold nanoshell upon being ligated by a SNP specific DNA ligase after binding of targets. As a result, we could detect as low as 20 attomoles of KRAS mutations within 1 h.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29687792
DOI: 10.1039/c8an00525g

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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