Article
Diagnostic and prognostic significance of neurofilament light chain NF-L, but not progranulin and S100B, in the course of amyotrophic lateral sclerosis: Data from the German MND-net.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Feb 2017
Steinacker Petra, Huss André, Mayer Benjamin, Grehl Torsten, Grosskreutz Julian, Borck Guntram, Kuhle Jens, Lulé Dorothée, Meyer Thomas, Oeckl Patrick, Petri Susanne, Weishaupt Jochen, Ludolph Albert C, Otto Markus
Abstract excerpt
There is a need for diagnostic, prognostic, and monitoring blood biomarkers for ALS. We aimed to analyse and compare proposed candidate markers for disease progression in the course of ALS. Blood samples were taken from 125 ALS patients, including nine patients with C9orf72 or SOD1 mutation, at regular intervals of six months. ALS patients were characterized by the ALS functional rating scale (ALSFRS-R) and the...
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