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Article

Plasma cardiac troponin T complements neurofilament light chain by reflecting disease phase and phenotypic variation in amyotrophic lateral sclerosis.

Journal of neurology - 27 Jul 2026

Sellin Julia, Öijerstedt Linn, von der Gablentz Janina, Chamoun Sanharib, Kläppe Ulf, Press Rayomand, Samuelsson Kristin, Grosskreutz Julian, Ingre Caroline

Abstract excerpt

BACKGROUND: Neurofilament light chain (NfL) is an established marker of neuronal injury and disease aggressiveness in amyotrophic lateral sclerosis (ALS). In contrast, the clinical and biological significance of cardiac troponin T (cTnT) in ALS is not fully understood. We aimed to evaluate the relationship between plasma cTnT and disease aggressiveness, progression stage, and clinical phenotype in comparison with...

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Identifiers

PMID: 42509459
DOI: 10.1007/s00415-026-14002-w
PMCID: PMC13407708

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