Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: A longitudinal, multicenter study.

doi:10.1111/ene.16379

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Article

Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: A longitudinal, multicenter study.

European journal of neurology - 1 Sept 2024

Meyer Thomas, Dreger Marie, Grehl Torsten, Weyen Ute, Kettemann Dagmar, Weydt Patrick, Günther René, Lingor Paul, Petri Susanne, Koch Jan Christoph, Großkreutz Julian, Rödiger Annekathrin, Baum Petra, Hermann Andreas, Prudlo Johannes, Boentert Matthias, Weishaupt Jochen H, Löscher Wolfgang N, Dorst Johannes, Koc Yasemin, Bernsen Sarah, Cordts Isabell, Vidovic Maximilian, Steinbach Robert, Metelmann Moritz, Kleinveld Vera E, Norden Jenny, Ludolph Albert, Walter Bertram, Schumann Peggy, Münch Christoph, Körtvélyessy Péter, Maier André

Abstract excerpt

OBJECTIVE: To assess the performance of serum neurofilament light chain (sNfL) in clinical phenotypes of amyotrophic lateral sclerosis (ALS). METHODS: In 2949 ALS patients at 16 ALS centers in Germany and Austria, clinical characteristics and sNfL were assessed. Phenotypes were differentiated for two anatomical determinants: (1) upper and/or lower motor involvement (typical, typMN; upper/lower motor neuron...

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PMID: 38859579
DOI: 10.1111/ene.16379
PMCID: PMC11295170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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