Article
Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.
Developmental cell - 21 Nov 2016
Shi Yuhao, Bollam Saumya R, White Shannon M, Laughlin Sean Z, Graham Garrett T, Wadhwa Mandheer, Chen Hengye, Nguyen Chan, Vitte Jeremie, Giovannini Marco, Toretsky Jeffery, Yi Chunling
Abstract excerpt
Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.