Article
Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis.
Cancer research - 15 Feb 2014
Menges Craig W, Kadariya Yuwaraj, Altomare Deborah, Talarchek Jacqueline, Neumann-Domer Erin, Wu Yue, Xiao Guang-Hui, Shapiro Irina M, Kolev Vihren N, Pachter Jonathan A, Klein-Szanto Andres J, Testa Joseph R
Abstract excerpt
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbestos-induced malignant mesothelioma compared wit...
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