Article
Elucidating distinct roles for NF1 in melanomagenesis.
Cancer discovery - 1 Mar 2013
Maertens Ophélia, Johnson Bryan, Hollstein Pablo, Frederick Dennie T, Cooper Zachary A, Messiaen Ludwine, Bronson Roderick T, McMahon Martin, Granter Scott, Flaherty Keith, Wargo Jennifer A, Marais Richard, Cichowski Karen
Abstract excerpt
BRAF mutations play a well-established role in melanomagenesis; however, without additional genetic alterations, tumor development is restricted by oncogene-induced senescence (OIS). Here, we show that mutations in the NF1 tumor suppressor gene cooperate with BRAF mutations in melanomagenesis by preventing OIS. In a genetically engineered mouse model, Nf1 mutations suppress Braf-induced senescence, promote...
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