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Article

A mouse model recapitulating molecular features of human mesothelioma.

Cancer research - 15 Sept 2005

Altomare Deborah A, Vaslet Charles A, Skele Kristine L, De Rienzo Assunta, Devarajan Karthik, Jhanwar Suresh C, McClatchey Andrea I, Kane Agnes B, Testa Joseph R

Abstract excerpt

Malignant mesothelioma has been linked to asbestos exposure and generally has a poor prognosis because it is often diagnosed in advanced stages and is refractory to conventional therapy. Human malignant mesotheliomas accumulate multiple somatic genetic alterations, including inactivation of the NF2 and CDKN2A/ARF tumor suppressor genes. To better understand the significance of NF2 inactivation in malignant...

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Identifiers

PMID: 16166281
DOI: 10.1158/0008-5472.CAN-05-2312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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