Article

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of <i>Nf2</i> -Deficient Malignant Mesothelioma

2020-07-01

Abstract excerpt

Malignant mesotheliomas (MM) show frequent somatic loss of the NF2 tumor suppressor gene. The NF2 product, Merlin, is implicated in several tumor-related pathways, including p21-activated kinase (PAK) signaling. Merlin is both a phosphorylation target for PAK and a negative regulator of this oncogenic kinase. Merlin loss results in PAK activation, and PAK inhibitors hold promise for the treatment of NF2 -defici...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44a817ca-b60d-5a88-9084-49a3a8cf62ad
DOI: 10.1101/2020.06.30.181453

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of <i>Nf2</i> -Deficient Malignant MesotheliomaDOI 10.1101/2020.06.30.181453Read

Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK PathwaysSemantic proximity Read

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in miceSemantic proximity Read

Validation of the p21-Activated Kinases as Targets for Inhibition in Neurofibromatosis Type 2Semantic proximity Read

Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis.Semantic proximity Read

PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2)Semantic proximity Read

Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.Semantic proximity Read

A conditional mouse model for malignant mesothelioma.Semantic proximity Read

A mouse model recapitulating molecular features of human mesothelioma.Semantic proximity Read

YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations.Semantic proximity Read

Inactivation of <i>Tp53</i> and <i>Pten</i> drives rapid development of pleural and peritoneal malignant mesotheliomasSemantic proximity Read

p21-activated Kinase Links Rac/Cdc42 Signaling to MerlinSemantic proximity Read

New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment.Semantic proximity Read