Article
Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.
Molecular cancer therapeutics - 1 Aug 2017
Cooper Jonathan, Xu Qingwen, Zhou Lu, Pavlovic Milica, Ojeda Virginia, Moulick Kamalika, de Stanchina Elisa, Poirier John T, Zauderer Marjorie, Rudin Charles M, Karajannis Matthias A, Hanemann C Oliver, Giancotti Filippo G
Abstract excerpt
Inactivation of NF2/Merlin causes the autosomal-dominant cancer predisposition syndrome familial neurofibromatosis type 2 (NF2) and contributes to the development of malignant pleural mesothelioma (MPM). To develop a targeted therapy for NF2-mutant tumors, we have exploited the recent realization that Merlin loss drives tumorigenesis by activating the E3 ubiquitin ligase CRL4DCAF1, thereby inhibiting the Hippo...
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