Article
Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas.
Experimental and molecular pathology - 1 Dec 2016
Fanourakis Galinos, Tosios Konstantinos, Papanikolaou Nikolaos, Chatzistamou Ioulia, Xydous Marios, Tseleni-Balafouta Sofia, Sklavounou Alexandra, Voutsinas Gerassimos E, Vastardis Heleni
Abstract excerpt
It has been demonstrated that APOBEC3B possesses cytidine deaminase activity, which is likely to result in C-to-T signature mutations. Increased expression of the APOBEC3B gene has been shown to correlate with higher incidence of such mutations in various cancer types, such as breast, bladder, lung, and head and neck carcinomas. In the current study, we used in silico methods, immunohistochemistry and qRT-PCR to...
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