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Article

Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.

Histopathology - 1 Mar 2023

Argyris Prokopios P, Naumann Jordan, Jarvis Matthew C, Wilkinson Peter E, Ho Dan P, Islam Mohammed N, Bhattacharyya Indraneel, Gopalakrishnan Rajaram, Li Faqian, Koutlas Ioannis G, Giubellino Alessio, Harris Reuben S

Abstract excerpt

AIMS: Primary head/neck mucosal melanomas (MMs) are rare and exhibit aggressive biologic behaviour and elevated mutational loads. The molecular mechanisms responsible for high genomic instability observed in head/neck MMs remain elusive. The DNA cytosine deaminase APOBEC3B (A3B) constitutes a major endogenous source of mutation in human cancer. A3B-related mutations are identified through C-to-T/-G base...

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Identifiers

PMID: 36416305
DOI: 10.1111/his.14843
PMCID: PMC10107945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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