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Article

Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants.

Nature genetics - 1 Nov 2006

Moreno-Loshuertos Raquel, Acín-Pérez Rebeca, Fernández-Silva Patricio, Movilla Nieves, Pérez-Martos Acisclo, Rodriguez de Cordoba Santiago, Gallardo M Esther, Enríquez José Antonio

Abstract excerpt

Common mitochondrial DNA (mtDNA) haplotypes in humans and mice have been associated with various phenotypes, including learning performance and disease penetrance. Notably, no influence of mtDNA haplotype in cell respiration has been demonstrated. Here, using cell lines carrying four different common mouse mtDNA haplotypes in an identical nuclear background, we show that the similar level of respiration among the...

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PMID: 17013393
DOI: 10.1038/ng1897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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