Article

Combination of mitochondrial tRNA and OXPHOS mutation reduces lifespan and physical condition in aged mice

2017-12-13

Abstract excerpt

Mutations in the mitochondrial DNA (mtDNA) are widely known to impact on lifespan and tissue integrity. For example, more than 250 pathogenic mtDNA mutations are known, many of which lead to neurological symptoms. In addition, major neurodegenerative diseases share key components of their etiopathogenesis with regard to mtDNA mutations, mitochondrial dysfunction and oxidative stress. In our study we used a set of...

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Literature Corpus work: 3c3e3231-81d3-5e45-8918-094d9e7ced44
DOI: 10.1101/233593

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