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Article

BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2017

Summers Matthew G, Smith Christopher G, Maughan Timothy S, Kaplan Richard, Escott-Price Valentina, Cheadle Jeremy P

Abstract excerpt

Purpose: Somatic mutation status at KRAS, BRAF, and NRAS is associated with prognosis in patients with advanced colorectal cancer (aCRC); however, it remains unclear whether there are intralocus, variant-specific differences in survival and other clinicopathologic parameters.Experimental Design: We profiled 2,157 aCRCs for somatic mutations in KRAS, BRAF, and NRAS and determined microsatellite instability status....

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Source

Identifiers

PMID: 27815357
DOI: 10.1158/1078-0432.CCR-16-1541

Genes

BRAF
NRAS
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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