BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.

doi:10.1158/1078-0432.CCR-16-1541

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Article

BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2017

Summers Matthew G, Smith Christopher G, Maughan Timothy S, Kaplan Richard, Escott-Price Valentina, Cheadle Jeremy P

Abstract excerpt

Purpose: Somatic mutation status at KRAS, BRAF, and NRAS is associated with prognosis in patients with advanced colorectal cancer (aCRC); however, it remains unclear whether there are intralocus, variant-specific differences in survival and other clinicopathologic parameters.Experimental Design:...

Topics

Aged
Colorectal Neoplasms
Female
GTP Phosphohydrolases
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Membrane Proteins
Microsatellite Instability
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymorphism, Single Nucleotide

Precision Medicine

Prognosis

Proportional Hazards Models

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed

Identifiers

PMID: 27815357
DOI: 10.1158/1078-0432.CCR-16-1541

Genes

BRAF
NRAS
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27815357-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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