Article
Clinicopathological characteristics and prognostic impact of colorectal cancers with NRAS mutations.
Oncology reports - 1 Jul 2014
Ogura Toshiro, Kakuta Miho, Yatsuoka Toshimasa, Nishimura Yoji, Sakamoto Hirohiko, Yamaguchi Kensei, Tanabe Minoru, Tanaka Yoichi, Akagi Kiwamu
Abstract excerpt
At present, molecular markers of colorectal cancer (CRC), including KRAS, NRAS and BRAF mutations, and the microsatellite status are evaluated for the development of personalized treatments. However, clinicopathological and molecular characteristics and the prognostic role of NRAS mutations remain unclear. In the present study, a total of 1,304 consecutive stage 0-IV CRC tumor samples were analyzed for KRAS (exon...
Topics
- Aged
- Colorectal Neoplasms
- DNA Mutational Analysis
- Female
- GTP Phosphohydrolases
- Humans
- Male
- Membrane Proteins
- Microsatellite Instability
- Mutation
- Neoplasm Staging