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Article

Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2017

Inaguma Shingo, Lasota Jerzy, Wang Zengfeng, Felisiak-Golabek Anna, Ikeda Hiroshi, Miettinen Markku

Abstract excerpt

The CD274 (PD-L1)/PDCD1 (PD-1) pathway is crucial for the modulation of immune responses and self-tolerance. Aberrantly expressed CD274 allows tumor cells to evade host immune system and is considered to be a mechanism of adaptive immune resistance. Inhibition of the CD274/PDCD1 immune checkpoint offers a promising new therapeutic strategy. Although CD274-expressing tumor cells have been identified in different...

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Source

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Identifiers

PMID: 27813511
DOI: 10.1038/modpathol.2016.185
PMCID: PMC7900912

Genes

ALCAM
CDX2
PDCD1
BRAF
SALL4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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