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Article

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

1 Mar 2021

Abstract excerpt

BACKGROUND: Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified. METHODS: Tumor tissues from 80 patients with dMMR CRC were evaluated for DKK1 expression and immune status via...

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PMID: 33782107
DOI: 10.1136/jitc-2020-001498

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