Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma.

Cancer science - 1 Jun 2014

Tamai Keiichi, Nakamura Mao, Mizuma Masamichi, Mochizuki Mai, Yokoyama Misa, Endo Hiroyuki, Yamaguchi Kazunori, Nakagawa Takayuki, Shiina Masaaki, Unno Michiaki, Muramoto Koji, Sato Ikuro, Satoh Kennichi, Sugamura Kazuo, Tanaka Nobuyuki

Abstract excerpt

Cholangiocarcinoma is an aggressive malignant tumor originating from intrahepatic or extrahepatic bile ducts. Its malignant phenotypes may be assumed by cancer stem cells (CSC). Here, we demonstrate that CD274 (PD-L1), known as an immunomodulatory ligand, has suppressive effects on CSC-related ph...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase
Share to B7-H1 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Duct Neoplasms

Share to Bile Ducts, Intrahepatic

Share to Cholangiocarcinoma

Share to Immunomodulation

Share to Mice, Inbred NOD

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 24673799
DOI: 10.1111/cas.12406
PMCID: PMC4317902

Genes

NOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24673799-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma.PMID 24673799Read ↗

Recent Advances in Understanding CholangiocarcinomaSemantic proximity Read ↗

Heterogeneity of Cholangiocarcinoma Immune BiologySemantic proximity Read ↗

Cancer stem cells in the development of liver cancer.Semantic proximity Read ↗

Immunogenomics of cholangiocarcinomaSemantic proximity Read ↗

CD271 Defines a Stem Cell-Like Population in Hypopharyngeal CancerSemantic proximity Read ↗

Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.Semantic proximity Read ↗

Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.Semantic proximity Read ↗

Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-CancerSemantic proximity Read ↗

Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?Semantic proximity Read ↗

Pleiotropic effects of DCLK1 in cancer and cancer stem cellsSemantic proximity Read ↗

Oncogenic driver genes and tumor microenvironment determine the type of liver cancerSemantic proximity Read ↗

Therapy-induced senescent-like cancer cells drive macrophage-mediated immunosuppression in cholangiocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.