Article

MS275 induces tumor immunosuppression by up-regulating PD-L1 and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer

2024-03-22

Abstract excerpt

<title>Abstract</title> <p>The histone deacetylase inhibitor MS275 (Entinostat) demonstrates anti-tumor effects against various types of solid tumors <italic>in vitro</italic>. But its effectiveness in clinical trials is limited. The underlying reasons remain to be determined. The purpose of this study was to explore how to enhance the anti-tumor effects of MS275 in colorectal cancer(CRC). Our data showed that MS...

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Literature Corpus work: 92c75a57-2065-5d05-8a9f-886c15338ce6
DOI: 10.21203/rs.3.rs-4133957/v1

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