DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.

doi:10.14670/HH-18-475

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Article

DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.

Histology and histopathology - 1 Aug 2022

Jansen Kristina, Kluth Martina, Blessin Niclas C, Hube-Magg Claudia, Neipp Michael, Mofid Hamid, Lárusson Hannes, Daniels Thies, Isbert Christoph, Coerper Stephan, Ditterich Daniel, Rupprecht Holger, Goetz Albert, Bernreuther Christian, Sauter Guido, Uhlig Ria, Wilczak Waldemar, Simon Ronald, Steurer Stefan, Burandt Eike, Perez Daniel, Izbicki Jakob R, Jacobsen Frank, Clauditz Till S, Marx Andreas H, Krech Till

Abstract excerpt

INTRODUCTION: The transmembrane channel protein DOG1 (Discovered on GIST1) is normally expressed in the gastrointestinal interstitial cells of Cajal and also in gastrointestinal stroma tumors arising from these cells. However, there is also evidence for a relevant role of DOG1 expression in colorectal cancers. This study was undertaken to search for associations between DOG1 expression and colon cancer phenotype...

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PMID: 35642329
DOI: 10.14670/HH-18-475

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