Article
PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2016
Rosenbaum Matthew W, Bledsoe Jacob R, Morales-Oyarvide Vicente, Huynh Tiffany G, Mino-Kenudson Mari
Abstract excerpt
Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key suppressors of the cytotoxic immune response. PD-L1 expression on tumor cells may be induced by the immune microenvironment, resulting in immune escape (adaptive immune resistance), and an adverse prognosis in many malignancies. In colorectal carcinoma the response to PD-1/PD-L1 inhibition is correlated with microsatellite instability. However, little...
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