Article
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
PloS one - 1 Jan 2016
Thiébaut Raphaële, Esmiol Sophie, Lecine Patrick, Mahfouz Batoul, Hermant Aurelie, Nicoletti Cendrine, Parnis Stephane, Perroy Julie, Borg Jean-Paul, Pascoe Leigh, Hugot Jean-Pierre, Ollendorff Vincent
Abstract excerpt
NOD2 contributes to the innate immune response and to the homeostasis of the intestinal mucosa. In response to its bacterial ligand, NOD2 interacts with RICK and activates the NF-κB and MAPK pathways, inducing gene transcription and synthesis of proteins required to initiate a balanced immune response. Mutations in NOD2 have been associated with an increased risk of Crohn's Disease (CD), a disabling inflammatory...
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