Article

Inborn errors E778K and G908R in NOD2 gene increase risk of nontuberculous mycobacterial infection: a computational study

2020-12-26

Abstract excerpt

<h4>Background</h4> The innate immune system has a critical role in the early detection of pathogens, mainly by relying on pattern-recognition receptor (PRR) signaling molecules. Nucleotide-binding oligomerization domain 2 (NOD2) is a cytoplasmic sensor for recognition of invading molecules and danger signals inside the cells. NOD2’s functions are critical; polymorphisms of its encoding gene are associated with s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fba07f08-d8dd-546c-b134-027662dc00ba
DOI: 10.1101/2020.12.25.424387

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inborn errors E778K and G908R in NOD2 gene increase risk of nontuberculous mycobacterial infection: a computational studyDOI 10.1101/2020.12.25.424387Read

Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome.Semantic proximity Read

Structural localization of pathogenic mutations in the central nucleotide-binding domain (NBD) of nucleotide-binding oligomerization domain-2 (NOD2) protein and their inference in inflammatory disorders.Semantic proximity Read

A Novel Rare Missense Variation of the <em>NOD2</em> Gene: Evidences of Implication in Crohn’s DiseaseSemantic proximity Read

Granulomatous nephritis associated with R334Q mutation in NOD2.Semantic proximity Read

Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans.Semantic proximity Read

The Influence of Single Nucleotide Polymorphisms of NOD2 or CD14 on Susceptibility to Tuberculosis: A Systematic ReviewSemantic proximity Read

NOD2 exonic variations in Iranian Crohn's disease patients.Semantic proximity Read

Novel missense mutation in the NOD2 gene in a patient with early onset ulcerative colitis: causal or chance association?Semantic proximity Read

Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases.Semantic proximity Read

The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review.Semantic proximity Read

NOD2 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis.Semantic proximity Read

The protein Nod2: an innate receptor more complex than previously assumed.Semantic proximity Read